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Changes Study

University of North Carolina at Chapel Hill


Description

The purpose of our study is to understand the role of estrogen fluctuation in combination with stressful life events in altering the normal biological responses to stress and, in so doing, triggering depression and anxiety symptoms. We also seek to examine whether stabilizing the estrogen fluctuation will have a beneficial effect on the biological responses to stress and mood symptoms.


Keywords:

Mental Health, Women's Health


Category:

Procedures

Qualifications

 


Age
45 - 60 years


Gender
Female


Study Population

Healthy women aged 45-60 currently in the menopause transition (having irregular menstrual cycles or skipped periods).


Investigator

Susan Girdler
Professor
Psychiatry - Research

For questions, contact:

Rachel Kozik
rachel_kozik@med.unc.edu
(919) 590-0813
Visit Website

Recruitment Period End

December 31, 2020

Location

Primary Location
UNC School of Medicine
2218 Nelson Hwy, Chapel Hill, NC 27517, USA
Secondary Location
UNC Women's Clinic
101 Manning Dr, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Female

Age Range 45 - 60 years

Participant qualification(s) Women aged 45-60 who are medically healthy, in the menopause transition (having irregular or skipped periods), and are currently experiencing symptoms of depression and anxiety.

Not eligible if: Current use of psychotropic medications, hormonal preparations, or certain herbal supplements (e.g. St. John's Wort or black cohosh). Currently suffer from, or have a history of: any cardiovascular disease, diabetes, cancer, bipolar disorder, or psychosis. Strong family history of breast, ovarian, or uterine cancer. BMI >37.

Number of Visits

    » 22 In person visit(s)

    1 enrollment, 1 gynecological exam, 6 lab sessions, 14 blood draws

    » 1 Remote visit(s)

    1 phone screen

Participation Period

24-28 weeks

Compensation

up to $1,275

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.