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Diabetes Prevention and Treatment Research Study

University of North Carolina at Chapel Hill


The goal of this study is to see if phlebotomy (like donating blood at the Red Cross) can improve blood sugar control and liver health. Preliminary studies in people and many studies in mice suggest that this may be the case. UNC researchers are investigating whether donating blood can help to reduce the risk for or symptoms of diabetes.







40 - 75 years


Study Population

Adults with prediabetes, type 2 diabetes, or risk factors for diabetes (e.g., elevated hemoglobin A1c within the last year).


John Buse
Verne S. Caviness Distinguished Prof

For questions, contact:

Niraja Pancholy
(919) 966-8484

Recruitment Period End

December 31, 2020


Primary Location
Clinical & Translational Research Center
Burnett-Womack Building, 160 Dental Cir, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 40 - 75 years

Participant qualification(s) Individuals age 40-75 who have been diagnosed with prediabetes or type 2 diabetes for at least three months, or have had an elevated A1c within the past year are eligible to participate.

Not eligible if: Individuals taking sulfonylureas, glinides, or insulin cannot participate. Individuals who have significant anemia, medical illness, organ failure, neurological disease, chronic inflammation, serious chronic infections, or an active cancer diagnosis (excluding skin cell cancers other than melanoma) cannot participate. Individuals who have experienced recent blood loss, have a history of orthostatic hypotension, or are currently being treated with anticoagulants cannot participate. Individuals who report heavy alcohol use or anticipate any upcoming major changes in lifestyle, diet, or exercise routine (other than those recommended by their regular doctor) cannot participate. Women of childbearing age ( < age 50) cannot participate unless they are on an effective program of birth control or are otherwise unable to become pregnant.

Number of Visits

    » 6-8 In person visit(s)

    6-8 Clinic Visits (1 Screening, 1 Continuous Glucose Monitor Placement Visit, 3-4 Phlebotomy Visits, 2 Follow-Up Visits)

    » 0 Remote visit(s)

Participation Period

1.5-2 years


$25-50 per completed visit.

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.