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ACL Reconstruction and Biofeedback Study

University of North Carolina at Chapel Hill


Individuals with a history of anterior cruciate ligament reconstruction (ACLR) are at a heightened risk for developing osteoarthritis. The heightened risk for developing osteoarthritis is likely caused by either too much force or too little force applied to the knee during tasks such as walking. In order to develop effective treatments that can change the force applied to the knee during walking, we must first determine what amount of force is beneficial for the knee following ACLR. The purpose of this research study is to determine if feedback about the force applied to each leg during walking can be used to alter force while walking. The feedback used in this study will display targets for average force, high force and low force. We will then determine the effect of average force, high force and low force on lower extremity movement patterns and markers of cartilage turnover and inflammation. You will be asked to complete 1 screening session (1.5 hours) and four testing sessions, with one week in between each session. Each testing session will last approximately 5 hours, (most of this time you will be sitting) therefore the entire duration of the study will be 21.5 hours over 5 weeks. If you choose to take part in the study you will complete the same assessments in the same order during each testing session. The assessments include: questionnaires, activity monitoring, blood draws, gait biomechanics assessment, and a walking biofeedback intervention.


Bones, Joints, Muscles, Pain, Pediatrics, Teens


Drug or Biologic



16 - 35 years


Study Population

Young adults (16-35) who have undergone ACL Reconstruction. Must be between 6 and 12 months post surgery and have had a bone patellar bone (BTB) autograft.


Brian Pietrosimone
Associate Professor
Exercise and Sport Science

For questions, contact:

Anne Wandishin
(703) 869-5572

Recruitment Period End

October 1, 2020


Primary Location
UNC Motion Analysis Lab
Fetzer Hall, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 16 - 35 years

Participant qualification(s) - Must be between the ages of 16 and 35 - Must be between 6 and 12 months post ACL reconstruction surgery - Must have had a Bone Patellar Bone (BTB) Autograft - Cannot be restricted by a physician from walking for 30 minutes or performing maximal voluntary contractions

Not eligible if: - If you have undergone ACLR revision surgery - If you have torn your ACL previously - If you had surgery for multiple ligaments in addition to your ACL. - If you have an immunodeficiency - If you are pregnant or planning to become pregnant during the next 5 weeks - If a lower extremity fracture was suffered during the ACL injury

Number of Visits

    » 5 In person visit(s)

    1-Screening, 4-Testing

    » 0 Remote visit(s)

Participation Period

5 weeks


$300 Visa gift card

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.