Back to list

Assessment of Gingival Inflammation in presence of Curcumin-containing toothpaste

University of North Carolina at Chapel Hill


Description

This study is designed to evaluate the anti-inflammatory potential of toothpaste containing the natural botanical curcumin.


Keywords:

Tooth/Dental


Category:

Device

Qualifications

 


Age
18 - 75 years


Gender
Any


Study Population

Adult individuals with generally healthy gingiva or with localized naturally occurring gingivitis will be enrolled.


Investigator

Silvana Barros
Associate Professor
Periodontology

For questions, contact:

Kristy Williams
kristyw@email.unc.edu
(919) 537-3420


Recruitment Period End

September 30, 2019

Location

Primary Location
Research Clinics - School of Dentistry
385 S Columbia St, Chapel Hill, NC 27599, USA
Secondary Location
Go Health research clinics
385 S Columbia St, Chapel Hill, NC 27599, USA

Study Qualifications

Gender Any

Age Range 18 - 75 years

Participant qualification(s) Participants must be adult males or females between the ages of 18 and 75 years (inclusive). • Participants must be able and willing to follow study procedures and instructions. • Participants must have read, understood and signed an informed consent form. • Participants must present with at least 8 teeth in the functional dentition and with at least 4 teeth in each posterior sextant, 3 of which are adjacent teeth with interproximal papilla in each posterior sextant that will have the stent. • Participants must be in good general health. • Participants must present with healthy periodontium or gingivitis (defined as PD≤4mm, BOP≥10%).

Not eligible if: • Patients with chronic periodontal disease. • Individuals who have a chronic disease with oral manifestations or active infectious diseases such as hepatitis, HIV or tuberculosis. • Individuals who exhibit gross oral pathology. • Treatment with antibiotics for any medical or dental condition within 1 month prior to the screening examination. • Chronic treatment (i.e., two weeks or more) with any medication known to affect periodontal status (e.g., phenytoin, calcium antagonists, cyclosporine, anticoagulants, non-steroidal anti-inflammatory drugs, high dose aspirin such as >100mg per day) within one month of the screening examination. • Ongoing medications initiated less than three months prior to enrollment (i.e., medications for chronic medical conditions must be initiated at least three months prior to enrollment). • Participants with clinically significant organ disease including impaired renal function, or any bleeding disorder. • Severe unrestored caries or any condition that is likely to require antibiotic treatment during the study, including the need for prophylactic antibiotic. • Individuals who use any tobacco products or who have used tobacco products within the previous twelve months of the screening examination. • Individuals who are pregnant, or expect to become pregnant within the next three months and individuals nursing. • Individuals with an allergy or sensitivity of oral care ingredients. • Individuals with sensitivity or allergies to Topical Anesthesia.

Number of Visits

    » 6 In person visit(s)

    1 screening, 5 clinic

    » 0 Remote visit(s)

Participation Period

35 days

Compensation

$200 at completion of the study

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.