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University of North Carolina at Chapel Hill


Mucus plugging is one of the causes of an asthma exacerbation, or "attack". With this study, we are asking people who have asthma which requires daily medication to keep in in control to inhale a strong salt water solution. We will use a lung scan to see how your lungs clear the mucus with the salt solution inhalations.


Asthma, Lungs


Drug or Biologic



18 - 60 years


Study Population

Adults with moderate to severe asthma which is well controlled on daily medication.


David Peden
Distinguished Term Professor
Pediatrics - Allergy Immunology and Rheumatology

For questions, contact:

Martha Almond
(919) 966-0759

Recruitment Period End

January 1, 2021


Primary Location
UNC Center For Environmental Medicine, Asthma and Lung Biology,
104 Mason Farm Rd, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 18 - 60 years

Participant qualification(s) Otherwise healthy, well controlled individuals who use a combination inhaler (bronchodilator and inhaled steroids) everyday for asthma.

Not eligible if: Participants must be currently healthy - no cold or flu symptoms, and must not have other major, uncontrolled medical problems.

Number of Visits

    » 8 In person visit(s)

    1 Screening visit, 1 baseline and follow up and 2 treatment and follow up visits.

    » 0 Remote visit(s)

Participation Period

3 1/2 months


If you complete the entire protocol you will earn $875

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.