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In-vivo effects of E-cigarette aerosol

University of North Carolina at Chapel Hill


To determine if e-cigarettes with Cinnamaldehyde (Cinnamon) flavoring impact the epithelial cell function as measured by mucociliary clearance (MCC)


Behavior, Breathing, Lungs, Smoking





18 - 40 years


Study Population

Adults ages 18-40 that use an e-cigarette device. Adults ages 18-40 that DO NOT use an e-cigarette device.


Ilona Jaspers
Pediatrics - Allergy Immunology and Rheumatology

For questions, contact:

Brian Ring
(919) 843-8472

Recruitment Period End

October 23, 2023


Primary Location
Center for Environmental Medicine, Asthma, and Lung Biology
104 Mason Farm Rd, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 18 - 40 years

Participant qualification(s) Subjects who currently use an e-cigarette device. -and/or- Subjects who do not use an e-cigarette device. Ages 18-40 Acceptable pulmonary function as measured in our lab

Not eligible if: Any pre-existing lung disease (e.g., asthma, cystic fibrosis, etc.) Any significant chronic illness, such as, but not limited to, heart disease, uncontrolled hypertension, diabetes, auto-immune disease Any use of tobacco products (other than e-cig) in the past 3 months, or a greater than 10 pack year history of smoking cigarettes. Pregnant or nursing women Subjects with a history of radiation exposure in the past year which exceeds annual safe limits.

Number of Visits

    » 3 visits for the control cohort, 7 visits of the vaping cohort In person visit(s)

    The contorl cohort (non-vapers) will have three visits that will consist of a (1) Screening visit, (2) baseline measurement, and (3) follow up visit. The vaping cohort will have the same first three visits as well as (4) Scan/Vaping visit, (5) Follow up visit. Visits (6) and (7) will occur after the crossover period.

    » 0 Remote visit(s)

Participation Period

Aproximatley two months


Non-vapers: $225 for full participation. Vapers: $750 for full participation

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.