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ASPIRE -for adults with Major Depression

University of North Carolina at Chapel Hill


Description

To rapidly reduce suicidality and symptoms of Major Depression, within 24 hours. This study is combined with standard of care (hospitalization, antidepressants, therapy, etc), and is placebo controlled. 8 treatments are provided after screening, with close follow up.


Keywords:

Brain/Head, Men's Health, Mental Health, Neurological Disorders, Older Adults, Sleep, Women's Health


Category:

Drug or Biologic
Phase:3

Qualifications

 


Age
18 - 64 years


Gender
Any


Study Population

Adults 18-64 with a current diagnosis of Major Depression and at risk for imminent suicidality. Must require hospitalization for current condition. Must be medically clear, no history of psychotic disorders or recent substance abuse. No current personality disorders.


Investigator

Robert McClure
Clinical Associate Professor
Psychiatry - General

For questions, contact:

Robert McClure
robert_mcclure@med.unc.edu
(984) 974-3854


Recruitment Period End

April 30, 2019

Location

Primary Location
UNC Neuroscience hospital
101 Manning Dr, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 18 - 64 years

Participant qualification(s) Current diagnosis of Major Depression, at high risk for suicide (intent within 24 hours), requiring hospitalization. Medically stable.

Not eligible if: Current diagnosis of substance abuse (moderate or severe) or personality disorders. Any history of psychosis or a psychotic disorder. Any history of hallucinogen drug use (except Marijuana) . Intellectual disability. Any participation of another clinical trial (drug or device) within 60 days.

Number of Visits

    » 16 In person visit(s)

    screening, treatment phase, and follow up. Some lab work and EKG's in 5 visits. surveys involved in all visits.

    » 2 Remote visit(s)

    25 Minute phone call, survey & check up

Participation Period

13 weeks

Compensation

$50 for traveling, $20 additional for outpatient dosing days, $25 for phone calls

By clicking I am interested, your contact information will be sent to the researcher/study coordinator for this study. The coordinator will respond by email with additional information on how to proceed.