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Serum and Urine Endogenous Compound Profiling in Autosomal Dominant Polycystic Kidney Disease

University of North Carolina at Chapel Hill


The purpose of this research study is to evaluate changes in liver protein function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to healthy volunteers and non-ADPKD patients with kidney disease. ADPKD is a common genetic disease where fluid-filled cysts develop and grow in both kidneys, leading to kidney failure. It affects about 1 out of every 1000 people worldwide. In some patients, the cysts also develop in the liver, causing some degree of liver impairment, which can have various ill consequences. There are many ways that the liver cysts could cause liver problems. Our study will test if the molecules (e.g. bile acids, coproporphyrins) in your blood and urine will be increased/decreased and if certain genes are different in different populations (i.e. healthy people vs patients). This will be determined from blood and collecting urine. Finally, scientists on our team will run analyses to detect the differences.


Kidneys, Liver, Urinary, Genetics





40 - 70 years


Study Population

Healthy participants


Vimal Derebail
Associate Professor

For questions, contact:

Jessica Murray

Recruitment Period End

July 1, 2020


Primary Location
Clinical & Translational Research Center
Burnett-Womack Building, 160 Dental Cir, Chapel Hill, NC 27514, USA

Study Qualifications

Gender Any

Age Range 40 - 70 years

Participant qualification(s) 1) age between 40 and 70 years at screening 2) ability to understand and sign an informed consent 3) negative blood pregnancy test (women of childbearing potential only)

Not eligible if: 1) donated blood within the last 30 days 2) are unable to come into the clinic 3) have a history of significant alcohol abuse and/or illicit drug use 4) are unable to not drink alcohol for 48 hours before the study visit 5) are unable to fast for 8 hours before the study visit 6) are diagnosed with HIV 7) have HCV but are not getting treated 8) have a history of diabetes or have been told that you have diabetes 9) taking concomitant medications, both prescription and non-prescription, other than oral contraceptives and multivitamins

Number of Visits

    » 1 In person visit(s)

    1 Clinic

    » 1 Remote visit(s)

    1 Phone

Participation Period

2-3 hours


$50 Visa gift card

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