68 Studies

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Current Studies

Study Name Category Keyword Description
Menstrually Related Mood Disorders Screening
Details
Registry, Healthy Volunteers Behavior, Mental Health, Women's Health Age: 18 - 52 years
Gender: Female
The primary purpose is to provide a mechanism for identifying patients with menstrually-related mood disorder (MRMD) who can participate in a variety of separate protocols. Those diagnosed with MRMD will be invited to participate in additional companion protocols.
NEPTUNE
Details
Registry Kidneys Age: 0 - 80 years
Gender: Any
The purpose of this study is to learn more about three kidney diseases called nephrotic syndrome: Focal Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD), and Membranous Nephropathy (MN). By collecting health information and laboratory samples from individuals who have these diseases and by making this information available to researchers, we hope to gain new knowledge about these diseases and to find better treatments for them.
Eating Disorders Research Registry
Details
Registry, Healthy Volunteers Behavior, Eating Disorders, Genetics, Mental Health, Nutrition, Obesity, Women's Health Age: 18 - 99 years
Gender: Any
At the UNC At the Center of Excellence for Eating Disorders, our mission is to better understand the causes and consequences of eating disorders in order to develop better treatment options. In pursuit of this mission, we conduct several research studies each year. To conduct these research studies, we need help from volunteers - individuals who want to help us better understand eating disorders. You can help by volunteering to join our research registry. Anyone can join our registry. We welcome volunteers with no history of an eating disorder, as well as volunteers with a current or past history of an eating disorder.
General Dental Screening
Details
Registry Genetics, Tooth/Dental Age: 18 - 65 years
Gender: Any
The GO Health Center is currently recruiting participants for general screenings to be added to our clinic registry. This will allow us to screen the registry for participants eligible for all our current and future studies. Participants can be screened for multiple studies at once instead of scheduling screenings for each individual study.
UNC Girls Health Study
Details
Behavioral, Healthy Volunteers Behavior, Mental Health, Pediatrics, Teens Age: 9 - 14 years
Gender: Female
The UNC Girls Health Study is designed to explore how girls adapt to the many new challenges of adolescence. We are interested in understanding how girls' friendships, family relationships, health risk behaviors, and emotional and physical reactions may be related to their future development. Your participation will help us learn more about the connection between adolescents' mental and physical health.
CogNiT
Details
Procedures, Healthy Volunteers Brain/Head, Mental Health, Pediatrics, Teens Age: 9 - 16 years
Gender: Any
This research study is designed to examine how the brain responds to stress in adolescents using state of the art methods for clinical assessments and brain imaging. Participants in this study need to have a brother, sister or parent with schizophrenia or bipolar disorder.
ARTFL
Details
Registry Behavior, Brain/Head, Genetics, Dementia, Neurological Disorders Age: 18 - 85 years
Gender: Any
This study aims to build a research network and registry for persons with Frontotemporal Lobar Degeneration (FTLD or FTD) in order to aid in future clinical trials.
IL-37
Details
Medical Treatment Outcomes, Healthy Volunteers Mouth/Nose/Throat, Tooth/Dental Age: 18 - 65 years
Gender: Any
to test whether the highly significant genetic variants of IL-37 underlie the hyper-inflammatory trait seen among periodontitis patients.
ADHD Study for Kids 8-12
Details
Behavioral, Healthy Volunteers Brain/Head, Developmental Disorders, Pediatrics Age: 8 - 12 years
Gender: Any
To test whether children with ADHD are impaired in the ability to flexibly adapt brain network organization in response to shifting cognitive demands during the exertion of cognitive control, by: 1) relating brain network dynamics in children with ADHD and typically developing (TD) children; and 2) assessing changes in network dynamics resulting from stimulant administration in children with ADHD, and how those changes relate to behavioral and symptom improvements.
The Microbiome and Postpartum Depression Study
Details
Behavioral, Healthy Volunteers Mental Health, Microbiome, Pregnancy, Women's Health Age: 18 - 45 years
Gender: Female
The purpose of this research study is to produce a better understanding of how pregnancy impacts the microbiota-gut-brain axis including the composition of the gut microbiota (the types of bacteria that live in the gut), the system that creates serotonin, and the stress system, particularly how the stress system adapts to handling psychological stressors. The goal of this study is to better understand how these three systems impact one another and may influence the risk of developing Postpartum Depression (PPD).
NIAAA Study of Binge Drinking
Details
Drug or Biologic, Healthy Volunteers Alcohol Abuse Age: 18 - 44 years
Gender: Any
The University of North Carolina at Chapel Hill is seeking volunteers for a research study testing the efficacy of the FDA approved medication bupropion in reducing binge drinking episodes. Bupropion is currently used to treat depression, but recently, studies have suggested that bupropion might be helpful in the treatment of binge drinking. The study will be "blinded" which means that neither you nor the study staff will know if you are taking bupropion or placebo. Participants will take the study medication for 3 months and attend 10 visits.
Changes Study
Details
Procedures, Healthy Volunteers Mental Health, Women's Health Age: 45 - 60 years
Gender: Female
The purpose of our study is to understand the role of estrogen fluctuation in combination with stressful life events in altering the normal biological responses to stress and, in so doing, triggering depression and anxiety symptoms. We also seek to examine whether stabilizing the estrogen fluctuation will have a beneficial effect on the biological responses to stress and mood symptoms.
Baby Connectome Project
Details
Procedures, Healthy Volunteers Behavior, Brain/Head, Pediatrics Age: 0 - 5 years
Gender: Any
The goal of this study is to further learn how a healthy human brain changes and works, specifically at a very young age. This study will help us learn more about children's mental, emotional and behavioral development, as well as understanding the possible causes of learning disabilities and neurodevelopmental disorders. This will be done by magnetic resonance imaging (MRI) scans of the child's brain during various times of development. Not only is MRI a safe and non-invasive procedure, but there will be no medication or sedation used for this study at any point.
Sulforaphane for the treatment of Autism Spectrum Disorder
Details
Drug or Biologic Autism Spectrum, Behavior, Developmental Disorders, Mental Health, Microbiome, Neurological Disorders, Pediatrics, Teens Age: 13 - 30 years
Gender: Male
The purpose of this research study is to determine if sulforaphane, a nutritional supplement made from broccoli sprout and seed extracts, is safe and effective for treating symptoms of autism in young men with moderate to severe autism spectrum disorder (ASD). Participants will take sulforaphane or placebo tablets for a total of 12 weeks, and caregivers will complete behavioral rating scales related to autism. We are also studying the effects of taking sulforaphane on the gut microbiome (bacteria in the digestive tract).
Asthma with Dust Mite Allergy Study
Details
Drug or Biologic Allergy, Asthma Age: 18 - 45 years
Gender: Any
The purpose of this research study is to help us understand which people who have asthma and who are allergic house dust mites, are more likely to have increased asthma symptoms a few hours after inhaling dust mites. If you have this drop in lung function, you may be invited to participate in other studies non-steroidal medication for asthma attacks.
Vitamin D Study
Details
Medical Treatment Outcomes Breathing, Lungs, Smoking Age: 18 - 80 years
Gender: Any
Researchers are testing the effects of vitamin D on blood and lung samples of regular smokers
Low Motivation and Pleasure
Details
Procedures Behavior, Mental Health Age: 18 - 50 years
Gender: Any
Researchers at UNC and Duke are evaluating a new talk therapy. They are looking for adults who are not currently taking any psychiatric medications and/or not currently in psychotherapy and are experiencing symptoms of low motivation and pleasure to participate in this study. Eligible participants will receive up to 15 therapy sessions from a Duke clinician at no cost in addition to other compensation.
PRIORITY
Details
Device Men's Health Age: 40 - 85 years
Gender: Male
Patients with previous negative prostate biopsy, but still considered at risk for prostate cancer may be eligible to take part in a study where they will have have further tests performed along with their scheduled repeat prostate biopsy. These research performed tests are being evaluated in hopes of making more accurate diagnosis and reduce the need for repeat biopsies.
Treatment Against RA and Effect on FDG PET-CT
Details
Drug or Biologic Arthritis, Auto Immune Diseases, Heart/Vascular, Joints Age: 45 - 99 years
Gender: Any
Examine the effect of Rheumatoid Arthritis modifying drugs on vascular inflammation. Compare the effects of vascular inflammation of achieving low disease activity or remission vs moderate-high disease activity,.
CHAT2D
Details
Drug or Biologic Diabetes, Pediatrics Age: 10 - 17 years
Gender: Male
The purpose of this study is to measure the safety and effectiveness of Exenatide Once Weekly (EQW) in children and teens with Type 2 Diabetes Mellitus (T2DM). This medication is injected one time per week to help manage Hemoglobin A1c and potentially help with weight loss. EQW is already approved for use in adults to manage T2DM.
Serum and Urine Endogenous Compound Profiling in Autosomal Dominant Polycystic Kidney Disease
Details
Procedures, Healthy Volunteers Kidneys, Liver, Urinary, Genetics Age: 40 - 70 years
Gender: Any
The purpose of this research study is to evaluate changes in liver protein function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to healthy volunteers and non-ADPKD patients with kidney disease. ADPKD is a common genetic disease where fluid-filled cysts develop and grow in both kidneys, leading to kidney failure. It affects about 1 out of every 1000 people worldwide. In some patients, the cysts also develop in the liver, causing some degree of liver impairment, which can have various ill consequences. There are many ways that the liver cysts could cause liver problems. Our study will test if the molecules (e.g. bile acids, coproporphyrins) in your blood and urine will be increased/decreased and if certain genes are different in different populations (i.e. healthy people vs patients). This will be determined from blood and collecting urine. Finally, scientists on our team will run analyses to detect the differences.
Milkshake Study
Details
Drug or Biologic Brain/Head, Diabetes, Nutrition, Obesity Age: 18 - 35 years
Gender: Any
This is a neuroimaging study looking at the brain's response to a milkshake and a drug for Type 2 diabetes. The goal is to see how a Type 2 diabetes drug affects how hungry a person feels. This study accepts healthy volunteers only.
COPD Registry
Details
Registry Behavior, Breathing, Lungs, Smoking Age: 40 - 99 years
Gender: Any
Researchers are looking for current and former smokers with or without COPD to enroll in a registry to be contacted for future studies.
DLB Consortium
Details
Registry Brain/Head, Dementia, Mental Health Age: 40 - 90 years
Gender: Any
This study aims to establish a research network and registry for persons with Dementia with Lewy Bodies (DLB) in order to characterize the disease and aid in future clinical trials.
FIT Study
Details
Medical Treatment Outcomes Digestion, Men's Health, Stomach, Women's Health Age: 18 - 99 years
Gender: Any
The purpose of this research study is to compare three different FDA approved treatments for fecal incontinence (also known as accidental bowel leakage) in men and women in terms of how well the treatments work, how safe the treatments are, and now much the treatments cost. The treatments are biofeedback therapy, sacral nerve electrical stimulation (SNS), or dextranomer injections.
Neuroimaging Study: Your Brain on Juice!
Details
Behavioral, Healthy Volunteers Behavior, Diabetes, Nutrition, Obesity Age: 18 - 28 years
Gender: Any
Be a part of a study focusing on the brain's response to juice intake over 3 weeks!
BestFIT Study
Details
Device, Healthy Volunteers Cancer, Digestion, Elderly, Men's Health, Older Adults, Women's Health Age: 50 - 85 years
Gender: Any
In this study, we are comparing five different fecal immunochemical tests (FITs) to determine how they compare with a doctor's findings during a routine colonoscopy. The FIT is a test that determines if there is hidden blood in the stool and is an alternative to colonoscopy for colorectal cancer screening when done annually.
BCG Strain Comparison
Details
Drug or Biologic Cancer Age: 18 - 99 years
Gender: Any
This study will evaluate differences and effectiveness of two treatments on bladder cancer. Patients with newly diagnosed High Grade Non Muscle Invasive Bladder cancer who meet qualifications will be treated with standard BCG treatment or with Tokyo-172 BCG.
Gilead-Lupus Membranous Nephropathy
Details
Drug or Biologic Lupus Age: 18 - 75 years
Gender: Any
To evaluate the efficacy of filgotinib and GS-9876 (both oral medications) in treating LMN (class V lupus nephritis)
Pilot Study: Chemotherapy and Cognition
Details
Behavioral, Healthy Volunteers Cancer, Older Adults Age: 18 - 75 years
Gender: Female
To examine whether cancer patients who have recently completed chemotherapy display cognitive impairments as compared to age-matched healthy control participants. Participants will participate in one approximately 2-3 hour study session, which will include questionnaires, cognitive computer tasks and neuropsychology tests.
Brain and Early Experience (BEE) Study
Details
Behavioral Behavior, Brain/Head, Microbiome, Nutrition, Pediatrics, Pregnancy, Sleep Age: 18 - 99 years
Gender: Female
The purpose of this study is to learn more about how experiences early in life influence children's brain development. The brain develops very quickly during the first two years of life. Understanding how early experiences help to shape the brain during infancy is important for improving children's long-term physical, emotional and behavioral health. This study will provide valuable information that we hope will inform future programs to help parents and educators better support children's early brain development and their long-term health.
UNC-Healthwise Birth Decision Aid Study (B-READY)
Details
Survey, Healthy Volunteers Pregnancy Age: 21 - 99 years
Gender: Female
The B-READY study is part of an effort to improve patient-centered care for patients who are deciding between a repeat cesarean or a trial of labor after cesarean (TOLAC). We are attempting to learn more about shared decision making between patients and their providers and if a decision aid tool is helpful in this process.
Black American Women and Social Cognition
Details
Behavioral, Healthy Volunteers Women's Health Age: 18 - 30 years
Gender: Female
African American women are currently underrepresented in psychological research studies. Please help us start to address this problem. UNC's Psychology department is looking for African American women aged 18 to 30 to participate in a research study about how people process social information. The study consists of completing a series of online questionnaires that will take 30 minutes, and one experimental session at UNC's campus that lasts 2 hours. The study pays $35 for completion.
EVOLVE Study
Details
Procedures, Healthy Volunteers Mental Health, Pediatrics, Teens, Women's Health Age: 12 - 14 years
Gender: Female
Starting at puberty, girls are more than twice as likely to be diagnosed with a mood disorder as boys. The goal of the EVOLVE study is to understand this gender disparity by examining the relationship between hormones, stress and mood in girls during the pubertal transition. This research study will involve mood assessments, hormone measurements, and an electroencephalogram (EEG) to look at brain activity.
anaSTILLs
Details
Drug or Biologic Arthritis, Auto Immune Diseases, Joints, Pain, Pediatrics Age: 0 - 0 years
Gender: Any
The aim of this study is to demonstrate the efficacy of anakinra in Still's disease.
In-vivo effects of E-cigarette aerosol
Details
Procedures Behavior, Breathing, Lungs, Smoking Age: 18 - 40 years
Gender: Any
To determine if e-cigarettes with Cinnamaldehyde (Cinnamon) flavoring impact the epithelial cell function as measured by mucociliary clearance (MCC)
Same-Sex Couples Counseling
Details
Behavioral Mental Health, Older Adults, Women's Health Age: 21 - 99 years
Gender: Female
I specialize in working with couples and am conducting a small treatment research study of a no-cost couple therapy program.
SLE - BMS Paisley Study
Details
Drug or Biologic Arthritis, Auto Immune Diseases, Joints, Lupus, Skin Age: 18 - 75 years
Gender: Any
This study is to help patients diagnosed with SLE that is currently on therapy but still having flares. The purpose is to decrease the flares and if subjects are on steroids decrease dose while on study.
Assessing MyChart Usability
Details
Survey, Healthy Volunteers Behavior Age: 18 - 99 years
Gender: Any
We would like to study patient perceptions regarding the usability and satisfaction of the MyChart patient portals at UNC Health Care as well as comparing the consenting process between in-person and online consent sessions. This is done through a semi- structured interview and brief surveys. This study should last less than one hour.
The 1289-0032 Research Study: Are your thoughts tangled?
Details
Drug or Biologic Mental Health Age: 16 - 30 years
Gender: Any
Are Your Thoughts Tangled? You're not sure how or why it happened, but you are aware of instances lately when it felt like you had no control over your thoughts. You couldn't think clearly or concentrate, and you may have even heard or seen things that other people didn't. While these were unsettling times, you eventually regained control of your thoughts. Still, you may be concerned about whether it will happen again and if it could be a sign of a more serious mental health condition. Because you and others have experienced symptoms like these, local doctors are conducting the 1289-0032 Research Study. In this study, doctors want to evaluate the safety and effectiveness of an investigational drug and compare it to placebo, which looks like the investigational drug but contains no active medication. The investigational drug is not approved to treat any mental health or medical condition. The results of this study will provide more information about the investigational drug and whether it could one day be used to help people who have experienced symptoms similar to yours.
SALTY
Details
Drug or Biologic Asthma, Lungs Age: 18 - 60 years
Gender: Any
Mucus plugging is one of the causes of an asthma exacerbation, or "attack". With this study, we are asking people who have asthma which requires daily medication to keep in in control to inhale a strong salt water solution. We will use a lung scan to see how your lungs clear the mucus with the salt solution inhalations.
(IFI)16 is a Periodontitis Modulating Protein
Details
Procedures, Healthy Volunteers Genetics, Men's Health, Microbiome, Mouth/Nose/Throat, Tooth/Dental, Women's Health Age: 18 - 99 years
Gender: Any
The purpose of this study is to evaluate how two specific proteins express themselves in the mouth when inflammation is induced. Understanding the expression of the proteins will help give insight to the underlying causes of periodontal disease. Ultimately this discovery may lead to new and improved ways to diagnose and treat periodontal disease in the future.
NEFECON for IgA Nephropathy
Details
Drug or Biologic Kidneys Age: 18 - 99 years
Gender: Any
This study is for patients diagnosed with Primary IgA Nephropathy, a kidney disease . it involves research and is conducted to determine the efficacy and safety of a drug called Nefecon (with the active ingredient, budesonide) The purpose of the study is to look at: • How well Nefecon works for the treatment of kidney disease and more specific for patients with the disease "primary immunoglobulin A nephropathy", called IgAN; and • How safe and effective Nefecon is compared to placebo.
Longitudinal Impulsivity and Alcohol Neuroimaging study
Details
Behavioral, Healthy Volunteers Alcohol Abuse, Behavior, Brain/Head, Mental Health, Substance/Drug Use, Teens Age: 18 - 19 years
Gender: Any
The purpose of this research study is to test whether individual tendency toward impulsive behaviors relates to alcohol drinking, whether connections between certain brain areas predict the association between these behaviors, and how these factors are influenced by genes and childhood environment.
Phase II M2951 study for Systemic Lupus Erythematosus (SLE)
Details
Drug or Biologic Arthritis, Auto Immune Diseases, Joints, Lupus, Skin Age: 18 - 75 years
Gender: Any
To possibly help reduce symptoms associated with Systemic Lupus Erythematosus (SLE).
Advancing Care for Type 1 Diabetes and Obesity Network Study (ACT1ON)
Details
Behavioral Auto Immune Diseases, Diabetes, Nutrition Age: 19 - 30 years
Gender: Any
The goal of this research study is to help young adults with Type 1 diabetes improve both their blood sugar management and their weight at the same time. A total of 84 adults will participate in this study. If participating, you will be in this study for about ten and a half months. This study will compare three specific diets (low fat/reduced calorie, low carbohydrate/reduced calorie or a Mediterranean-based eating plan).
Physical Activity in Pregnancy Study
Details
Device, Healthy Volunteers Heart/Vascular, Obesity, Pregnancy, Women's Health Age: 18 - 99 years
Gender: Female
Researchers at the UNC School of Nursing need your help to learn more about which physical activity monitor is most accurate and comfortable to use during pregnancy.
ACADIA Neurodegenerative Disease and Psychosis
Details
Drug or Biologic Alzheimer's, Behavior, Dementia, Elderly, Neurological Disorders, Older Adults Age: 60 - 99 years
Gender: Any
To assess the safety and tolerability of pimavanserin compared to placebo in adult and elderly subjects with neuropsychiatric symptoms related to neurodegenerative disease
ORBEX Study
Details
Drug or Biologic Asthma, Pediatrics Age: 0 - 0 years
Gender: Any
The primary objective of this study is to evaluate if the study drug when given to infants (6-18 months who are at a higher risk of developing asthma) for 10 days monthly for two consecutive treatment years can increase the time to the occurrence of the first wheezing episode during a third observation year while off of study drug therapy.
VOR-07 Study
Details
Drug or Biologic HIV/AIDS Age: 18 - 64 years
Gender: Any
This study is looking at combining 2 medications to evaluate the ability of the combination to decrease the size of the latent reservoir. We will test the use of an antibody called VRC07-523LS to stimulate the immune system to fight HIV infection. We will give the drug Vorinostat (VOR) to stimulate the release of HIV from the latent reservoir. Previous research studies show that VOR has the ability to stimulate some non-active HIV infected cells to become active and release HIV virus. The purpose of this study is to: • Evaluate the safety of VOR in combination with VRC07-523LS • Evaluate the safety of two series of a VRC07-523LS infusion followed by multiple oral doses of VOR • Determine if combining VRC07-523LS and VOR can have an impact on the size of the latent reservoir.
Orofacial Pain and Headache Research Participant Registry
Details
Registry, Healthy Volunteers Pain, Tooth/Dental Age: 18 - 99 years
Gender: Any
The participant registry will assist with study recruitment for current and future studies at the UNC-CH School of Dentistry.
UNITE: Uniting Couples in the Treatment of Binge-Eating Disorder
Details
Medical Treatment Outcomes Behavior, Eating Disorders, Mental Health, Nutrition, Obesity Age: 18 - 99 years
Gender: Any
The purpose of this study is to compare two treatments for individuals with binge-eating disorder (BED) who are in committed relationships.
Adolescence Astellas
Details
Drug or Biologic Allergy, Pediatrics Age: 12 - 17 years
Gender: Any
The primary objective of this study is to evaluate the safety and tolerability of an investigational vaccine to prevent allergic reactions in adolescent subjects with peanut allergy.
Relationship Communication Study
Details
Survey, Healthy Volunteers Behavior Age: 22 - 99 years
Gender: Any
The Psychology Department at UNC is conducting a research study to learn more about the experiences of individuals in committed relationships.
COPD Trial to Reduce Exacerbations
Details
Drug or Biologic Breathing, Lungs, Smoking Age: 40 - 75 years
Gender: Any
The goal of this study is to understand if an investigational medication reduces the number of exacerbations you have in a year. Participants will either be given the active medication or a placebo (inactive solution that does not contain medication) as an injection given every two weeks in clinic for one year.
Finch CDI-001 Prism 3
Details
Drug or Biologic Digestion, Microbiome, Stomach Age: 18 - 99 years
Gender: Any
The purpose of this research study is to evaluate effectiveness and potential side effects of taking the test medicine versus a placebo to prevent recurrent Clostridium difficile infection (CDI). The test medicine, CP101, has not been approved by the FDA to treat or prevent recurrent CDI; its use in this study is investigational. By comparing people's responses to the placebo and to the test medicine being studied, researchers can tell whether the test medicine is having any benefit to prevent recurrent CDI.
Freenome
Details
Registry, Healthy Volunteers Cancer, Genetics, Older Adults, Digestion Age: 50 - 84 years
Gender: Any
The purpose of this study is to collect blood or stool to develop new and improved tests to detect and treat colon cancer in the future.
ORKIDS
Details
Drug or Biologic Auto Immune Diseases Age: 18 - 99 years
Gender: Any
The main purpose of this research is to investigate whether treatment with Krill Phospholipids Concentrate (AKBM-3031) also known as Krill Oil is able to replenish the omega-3 deficiency associated with Systemic Lupus Erythematous (SLE). Omega-3 is an essential nutrient that is important in preventing and managing heart disease. In addition, this study is also being done to determine whether taking the Krill Oil has further positive effects in SLE patients with regards to slowing down the progression of and/or preventing disease flares. SLE is a disease that affects the immune system and can affect any part of the body (skin, joints, and/or organs).
Identification of allergic asthmatics sensitive to cat hair allergen
Details
Drug or Biologic Allergy, Asthma, Breathing, Lungs Age: 18 - 45 years
Gender: Any
This is a study to identify subjects with LAR to inhaled cat hair allergen for potential participation in subsequent treatment studies.
GSK V72_57: Safety and Immunogenicity of GSK Meningococcal Group B vaccine and 13-valent Pneumococcal Vaccine administered with routine vaccines
Details
Drug or Biologic, Healthy Volunteers Pediatrics Age: 0 - 0 years
Gender: Any
Primary objective of this study is to test the immune response and safety of a meningitis B vaccine when administered concomitantly with routine infant vaccines in healthy infants age 6-12 weeks.
Periodontal (Gum) Disease Treatment Study
Details
Medical Treatment Outcomes, Healthy Volunteers Behavior, Men's Health, Mouth/Nose/Throat, Older Adults, Tooth/Dental, Women's Health Age: 18 - 75 years
Gender: Any
To evaluate the safety and effectiveness of the Periodontal Structure Repair (PSR) procedure to assist with the treatment of periodontal pockets versus standard root planing (SRP).
EMPA-KIDNEY
Details
Drug or Biologic Diabetes, Kidneys Age: 18 - 0 years
Gender: Any
Scientists are searching for new treatments to reduce the risk of kidney and heart problems in people with kidney disease. There is now a new medication called empagliflozin which was originally developed to treat high blood sugar in people with diabetes but has recently been shown to have beneficial effects on both the heart and kidney.
RADIANCE II
Details
Device Heart/Vascular, High Blood Pressure Age: 18 - 75 years
Gender: Any
The purpose of this study is to evaluate the safety and effectiveness of renal denervation (an experimental procedure that decreases nervous system activity involved in the control of blood pressure) using Recor Medical's Paradise Renal Denervation System in patients with Stage 2 hypertension on up to two medications.
Wrist Fracture Evaluation with Tomo-E
Details
Device Bones, Hands Age: 12 - 99 years
Gender: Any
The primary objective is to compare (using a reader study) the sensitivity of Tomo-E compared to radiography of the wrist in detecting wrist fractures. The secondary aim is to determine the specificity of Tomo-E compared to radiography of the wrist in detecting wrist fractures.
Assessment of Gingival Inflammation in presence of Curcumin-containing toothpaste
Details
Device, Healthy Volunteers Tooth/Dental Age: 18 - 75 years
Gender: Any
This study is designed to evaluate the anti-inflammatory potential of toothpaste containing the natural botanical curcumin.
Phase 2 study for Adults with Chronic Rhinosinusitis with Nasal Polyps Study
Details
Drug or Biologic Allergy, Asthma, Breathing, Mouth/Nose/Throat Age: 18 - 65 years
Gender: Any
The purpose of this clinical trial is to test the safety and effectiveness of the study drug, etokimab (ANB020).
Hearing study - 60 to 85 year-old adults with normal hearing
Details
Behavioral, Healthy Volunteers Hearing, Older Adults Age: 60 - 85 years
Gender: Any
The purpose of our research is to obtain a better understanding of hearing. During the course of the study, you will sit in a soundproof booth and listen to sounds presented over headphones. When a target sound is heard, you will be prompted to make a response by pressing a button on a response box.
GDCN Registry
Details
Registry, Healthy Volunteers Behavior, Kidneys, Pediatrics, Urinary Age: 0 - 99 years
Gender: Any
This is an observational study that uses clinical data and biological specimens (like blood) collected on a large group of participants with and without kidney disease. Researchers are trying to learn about the causes and markers of kidney disease.